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Despite no evidence of a fall in demand Postalisch-2010, prices settled down to 2007 levels by late 2013, indicating that supply increased enough to satisfy demand. DEA price data, however, are gathered predominantly from larger cities, potentially missing heroin shortages and price variation further down the supply chain hinein small towns and Ländlich areas.There's a Harte nuss loading this page There welches a Harte nuss loading a critical resource, which prevents the page from continuing.
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Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. Can Med Assoc J
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Fentanyl self-testing outside supervised injection settings to prevent opioid overdose: do we know enough to promote it?
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Illicitly manufactured fentanyl and its analogues are appearing in countries throughout the world, often disguised as heroin or copyright prescription pills, with resulting high overdose mortality. Possible explanations for this phenomenon include reduced costs and risks to heroin suppliers, heroin shortages, user preferences for a strong, fast-acting opioid and the emergence of Dark Netz cryptomarkets.
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Motivations for suppliers to add fentanyl to street opioids are probably profit-oriented with an eye towards future sustainability. By dose-equivalency, fentanyl is orders of magnitude cheaper to produce than heroin [39] and entirely synthetic, protected from the vicissitudes of climate and plant diseases.
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schwere andauernde Schmerzen, die nichts als mit opioiden Schmerzmitteln ausreichend behandelt werden können
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Together, these supply shocks may have spurred the introduction of fentanyl-as-substitute hinein 2013, which occurred rein the US Northeast and Midwest regions formerly supplied by Colombian-sourced heroin. Despite a recovery hinein total opium production hinein 2015 to above 2009 levels, fentanyl and other synthetic substitutes persist.